DEAR READERS: Regarding the recent news about Tylenol, please see the following write-up from Nature.com, posted Sept. 23:
"'Don’t take Tylenol,' was the blunt advice of President Donald Trump during an announcement that the U.S. Food and Drug Administration will slap a new warning label on the painkiller (also known as acetaminophen and paracetamol) that flags a 'possible association' with autism in children. But there is a lack of strong evidence to back up the claim. Association does not mean causation. 'The evidence does not support a causal link between acetaminophen or vaccines and autism,' says clinical teratologist Sura Alwan, the executive director of PEAR-Net Society, a nonprofit advocating for maternal fetal health and research. There are few safe alternatives to treat pain and fever during pregnancy, so advising against it is 'bound to increase fear in pregnant women,' says Helen Tager-Flusberg, a psychologist who studies autism. 'It is absolutely not grounded in the scientific findings.'"
The Trump administration has announced that a drug called leucovorin (or folinic acid), currently used to treat the side effects of cancer drugs, will be made available to treat symptoms of autism in some children.
How this essential nutrient may help autism symptoms, if it does, is unknown, but its role in neurologic development has been long recognized. Folate deficiency is a significant risk factor for spina bifida and other neural tube defects. Women of childbearing age have long been advised to consume folic acid through supplements and fortified foods.
There are significant unknowns regarding the use of leucovorin to treat autism. From Nature.com, Sept. 24:
"Some specialists warn that the drug's efficacy has not been established, that scientists don’t know how much of the drug to give or how long people should take it, and that safety data in children are lacking. According to the FDA’s current plans, leucovorin will be available to only a minority of autistic people. All of this has led to widespread confusion, say clinicians. 'If anyone tells you they have found a magic bullet cure for autism, doubt them,' says Alycia Halladay, chief science officer of the Autism Science Foundation. 'There is not going to be one cause and one singular treatment.'"
Continued, from Nature and Scientific American:
"The FDA’s proposed approval, which has not yet been finalized, would apply only to people with low levels of folate in the fluid surrounding the brain and spinal cord. That represents about 7% to 30% of autistic people, depending on how folate levels are measured," says Halladay. "'Families are in the Facebook groups saying, "We can get a prescription now," she says. 'And that’s not what's going to happen.'"
In my opinion, when looking into contributing factors for autism, the Department of Health and Human Services should examine the pesticide contaminants in our food and water. These substances are also put on millions of pets to prevent fleas and ticks, and can then be inadvertently ingested by family members after petting the animals.
To that end, see the study "Are the growing levels of neurotoxic and neuro-disruptive chemicals in our food and drink contributing to the youth mental health crisis? A narrative review" by J.J. Newson et al., published in Neuroscience and Biobehavioral Reviews in 2025.
Here is an excerpt from that study's abstract:
"Over the past few decades, there has been a marked and largely unexplained decline in the mental health and well-being of young people worldwide. One such factor, often overlooked, is the increasing exposure of children and adolescents to neurotoxic and neuro-disruptive chemicals in the food and beverages they consume. These include agricultural and industrial chemicals (e.g., pesticide residues, heavy metals), additives in ultra-processed foods, and packaging-derived contaminants such as microplastics and bisphenols. ... Altogether, the widespread presence of these neurotoxic and neuro-disruptive chemicals in the body and brain, and growing reports of their adverse impacts on behavior, cognition, and mental health in young people, points to the potential for progressive degradation of brain function that poses a grave threat to the future well-being of society and underscores the urgent need for increased research, funding, and regulation in this area."
Decades of research suggests that genetics plays a huge part in the development of autism, although a string of environmental factors have also been linked to it.
“There will never be a sound-bite answer to what causes autism,” says Tager-Flusberg. Meanwhile, many experts say the increasing prevalence of autism is predominantly caused by an increase in diagnoses and awareness rather than a true rise in occurrence.
As for companion animals, scientists have selectively bred dogs with symptoms of autism for research purposes, and I believe some cats may have a similar condition. Some dogs and cats may prefer to be feral, remaining averse to human contact. Some engage in compulsive behaviors, like the many bull terriers who have been documented to obsessively chase their tails. Cats can develop the equivalent brain disease to Alzheimer’s, so one may consider there could be a similar parallel with autism. For more, read veterinarian Patrica Jordan's article here: dogsnaturallymagazine.com/can-dogs-have-autism.
In my opinion, there are multiple environmental factors that can influence brain development. I am especially concerned about pre- and post-natal exposure to the nonionizing radiation and electromagnetic fields of telecommunication systems. For details, see my post here: drfoxonehealth.com/post/electropollution-existential-threat-to-public-health-and-life-on-earth.
(Send all mail to animaldocfox@gmail.com or to Dr. Michael Fox in care of Andrews McMeel Syndication, 1130 Walnut St., Kansas City, MO 64106. The volume of mail received prohibits personal replies, but questions and comments of general interest will be discussed in future columns.
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